![]() 6 Despite of more advanced prognostication factors, NPI is internationally validated system for classifying early & locally advanced breast cancer into three prognostic groups. 5 This NPI further divides patients into three prognostic groups as good (5.4). 4 Among all, three most powerful prognostic factors as tumor size, lymph node status & histopathological grade we re incorporated into Nottingham Prognostic Index (NPI) first described in 1982. They can be also used to distinguish patients likely to have recurrence after treatment of primary tumor, from those with low risk of recurrence and those likely to benefit from adjuvant therapy. 3 These prognostic factors influence design, conduct and analysis of clinical trials in breast cancer. Multiple clinico-pathological- molecular prognostic and predictive factors ranging from patient’s age to recent most gene expression profiling are available in decision making about potentially suitable treatment options for breast cancer. 1 It has been ranked number one cancer among the Indian females surpassing the incidence of cervical cancer. Main strength of NPI lies in the fact that it is based on relatively simple data which can be provided in routine histopathology report of carcinoma breast.īreast cancer is the most frequent malignancy in woman accounting for approximately 15% of female cancer death and leading cause of death in women aged between 44-50 years. Among 7 variables, NPI was found to be statistically most significant with p value 0.001Ĭonclusion: Estimation of NPI is the powerful and reproducible index for assessing prognosis in patients with operable breast cancer in advanced resources deprived institute. Out of 60 patients, 34 patients had a follow up of more than 1000 days, so were included in statistical analysis of survival based on Cox Proportional Hazard Model. ![]() Four patients from poor prognostic group had death within two and half year s of primary diagnosis. Five patients from poor prognostic group had metastasis in liver, bone, CNS and lung with two patients had simultaneous metastasis in liver & bone. However the worst outcome was found in patients from poor prognostic group (NPI > 5.4) (10%). ![]() F rom moderate prognostic group ((NPI 3.4 - 5.4) (50%), one patient had recurrence at previous surgical scar site and 3 patients had metastasis to liver, lung and supraclavicular lymph node each. Results: Two patients from good prognostic group (NPI ≤3.4) (30%) had metastasis to bone & CNS. Materials and Methods: This longitudinal (Descriptive) study was carried on 60 female patients of operable breast carcinoma at tertiary care centre in central India. Present study aimed to evaluate the significance of NPI in prognosis of operable breast cancer patients. Among all, Nottingham Prognostic Index (NPI) is the most powerful integrated index. Multiple clinico-pathological-molecular prognostic factors are available in decision making about potentially suitable treatment options for breast cancer. Introduction: Breast cancer has been ranked number one cancer among the Indian females surpassing the incidence of cervical cancer.
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